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Alias names |
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Myotrophin, Protein V-1, GCDP
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Sequence |
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MGSSHHHHHH SSGLVPRGSH MCDKEFMWAL KNGDLDEVKD YVAKGEDVNR TLEGGRKPLH YAADCGQLEI LEFLLLKGAD INAPDKHHIT PLLSAVYEGH VSCVKLLLSK GADKTVKGPDGLTAFEATDN QAIKALLQ
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Concentration |
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1 mg/ml (determined by Bradford assay)
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Substrate/Buffer |
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Liquid. In 20 mM Tris-HCl Buffer (pH 8.0) containing 10% Glycerol
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Storage |
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Can be stored at +4°C short term (1-2 week). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles
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References |
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Sen S., et al. (2008) J Biol Chem. 283(41):27947-56
Sivasubramanian N., et al (2002) J Biol Chem. 277(26):23888-97
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Notes |
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MTPN (myotrophin), an ankyrin repeat protein, is stimulates protein synthesis and cardiomyocyte growth to initiate cardiac hypertrophy by activating the NF-kappaB signaling cascade. This protein plays a potential role in cerebellar morphogenesis and may function in differentiation of cerebellar neurons, particularly of granule cells. Elevated levels of MTPN are expressed in human dilated cardiomyopathic and ischemic hearts. Recombinant human MTPN, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.
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