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Alias names |
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Calcium binding protein 39, CGI-66, MO25
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Concentration |
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1 mg/ml (determined by Bradford assay)
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Substrate/Buffer |
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Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10% glycerol
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Storage |
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Can be stored at +4°C short term (1-2 week). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles
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References |
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Baas AF., et al. (2004) Trends Cell Biol. 14(6):312-9
Boudeau J., et al. (2003) EMBO J. 22(19):5102-14
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Notes |
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Calcium binding protein 39, also known as CAB39, is a 40-kDa protein that, together with the STE20-related adaptor-alpha (STRAD alpha) pseudo kinase, forms a regulatory complex capable of stimulating the activity of the LKB1 tumor suppressor protein kinase. Also CAB39 may function as a scaffolding component of the STK11/STRAD complex and regulates STK11 activity and cellular localization. Recombinant human CAB39, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques
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