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Alias names |
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Integrin beta-1, ITGB1, CD29, VLA-beta, ITGB1, FNRB, MDF2, MSK12, Integrin beta-1, Fibronectin receptor subunit beta, Integrin VLA-4 subunit beta
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Substrate/Buffer |
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50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA
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References |
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1. SF Schlossman et al. Oxford 1612-1613, 1995.
2. H Li et al. Blood 102(10):3652-3657, 2003.
3. C Cayrol et al Oncogene, 25:4421
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Notes |
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Integrin beta-1 (ITGB1, CD29, VLA-beta) is the beta subunit found in the integrin families, forming a heterodimer integrin receptor through non-covalent bonding with various integrin alpha subunits. Integrin heterodimer containing Integrin beta-1 binds to various cell surface and extracellular proteins (CD49a-f, CD51) to mediate cell to cell and cell to matrix adhesion (1). Integrin beta-1 plays a critical role in the cell adhesion and recognition in embryogenesis, hemostasis, immune response, tissue repair, metastatic diffusion of tumor cells and development (2, 3, 4).
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