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Toll like Receptors (TLR’s),

 

Visualize neurodegenerative changes and explore TLR’s mediator function in this scenario.


  Toll Like Receptor’s was discovered 20 years ago, and Toll-gene was first described in Drosophila. The name “Toll” is german and means “great/amazing” and reflects the researchers view how Drosophila appeared with or without knockout Toll-gene. TLR’s belong to the IL-1/TLR superfamily and is central in immunology. TLR plays an essential role in innate immunity and in B- T-cell mediated adaptive immunity. Different TLR’s has different pathogen recognition pattern. Nomenclatur of TLR is numerical 1-15.

TLR’s are activated by exo- and endogenous ligands. For example TLR3 reacts on RNA from viruses AND ruptured mammalian cell RNA (interests in Alzheimer disease). TLR2 has been shown to be enhanced in response to amyloid-beta in microglia cells. TLR4 expression is increased in brain tissue of Alzheimer disease patients . TLR has an increasing role in adaptive immunology and might be a unique key for immunological and pathological scenarios.

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Explore our portfolio of TLR’s - Purchase 2 or more TLR-products and receive 20% discount.
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Product      Cat# - Western Blot Cat# - Flow Cytometry
TLR1 IMG-5012 IMG-512
TLR2 IMG-416A IMG-416C
TLR3 IMG-315A IMG-315C
TLR4 IMG-5031A IMG-417C
TLR5 IMG-664A IMG-663C
TLR6 IMG-304A IMG-304C
TLR7 IMG-540 IMG-665A
TLR8 IMG-321A IMG-321C
TLR9 IMG-305A IMG-305C
TLR10 IMG-5630 IMG-386


View all our Toll Like Recptor related products 


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Available literature

 
Toll Like Receptor folder
 
or
 
  
Toll Like Receptor poster