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The SLC group of membrane transport proteins include over 300 members organized into 47 families based on genetic homology. E.g. the SLC25 family of mitochondria associated carriers consists of 46 different subtypes in itself.
Carrier families tend to be associated with specific organs, and defects in carrier function often cause specific diseases. The kidney, liver and nervous system are heavily dependent on the use of solute carrier proteins. Among typical specific disorders is the Glucose Malabsorption Syndrome, originating from a defect among the SLC5 family.
Please take advantage of our extensive range of SLC antibodies to identify the transporters in your protein of interest and gain insight into its role in cell regulation. |