The C-X-C or alpha chemokine family is characterized by a pair of cysteine residues separated by a single amino acid; it primarily functions as chemoattractant for neutrophils.

 

The C-X-C family includes IL-8, NAP-2, MSGA and stromal cell derived factor-1 (SDF-1). SDF-1 (CXCL12) was originally described as a pre-B cell stimulatory factor, but has since been shown to function as a potent chemoattractant for T cells and monocytes, but not neutrophils. Receptors for the C-X-C family are G protein-coupled, seven pass transmembrane domain proteins which include IL-8RA, IL-8RB, CXCR and fusin (also designated LESTR or CXCR-4).

 

CXCR3, also known as IP-10/MIG receptor or CD183, mediates Ca2+ mobilization and chemotaxis in response to the C-X-C chemokines IP-10 (CXCL10), MIG (CXCL9), I-TAC (CXCL11) and PF-4 (CXCL4). CXCR3, molecular weight 38 kDa, is highly expressed on IL-2 activated T lymphocytes, but not on resting T lymphocytes, B lymphocytes, monocytes or granulocytes.

 

 

Description	Clone	Application	Cat #
Alexa Fluor 647 anti-mouse CD183 (CXCR3)	CXCR3-173	FC	126508
Biotin anti-mouse CD183 (CXCR3)	CXCR3-173	FC	126504
LEAF purified anti-mouse CD183 (CXCR3)	CXCR3-173	FC, FA	126510
PE anti-mouse CD183 (CXCR3)	CXCR3-173	FC	126506
Purified anti-mouse CD183 (CXCR3)	CXCR3-173	FC	126502